Immunoglobulin E-Mediated Anaphylaxis to Sesame

نویسندگان

  • Emmanuella Guenova
  • Sonya Genova
  • Bogomil Voykov
  • Silvia Novakova
  • Vanyo Mitev
چکیده

To the Editor: The incidence of food allergy is age dependent, particularly affecting children and young patients. When selfreported, it ranges between 3% and 35%. However, placebocontrolled food challenge is positive in just 1% to 4% of all suspected cases. In elderly, anaphylactic reactions tend to be less severe, and a primary manifestation at this age is unusual. A 70-year-old white man needed twice in the past 6 months emergency medical help because of acute systemic anaphylactic reactions, both timely associated with sesame (Sesamum indicum) ingestion. Fifteen minutes after consumption of sesame-poppy-raisin sweets or sesame bread, the patient developed generalized urticaria with periorbital, periocular, and laryngeal edema associated with severe hypotension and unconsciousness. In both cases, emergency treatment with intramuscular administration of epinephrine and high doses of corticosteroids and antihistamines intravenously was needed. Previous allergic reactions were denied. Occasional contact to sesame throughout the life span and noncontributory further own and familial anamnesis were stated. Skin prick tests to common inhalant allergens, housedust mite, preservatives, and food allergens were negative. Furthermore, prick-to-prick tests with poppy seed, raisins, and wheat flour remained negative as well. Surprisingly, skin prick-to-prick tests, both with sesame seed and sesame oil, revealed a pronounced positive reaction compared with the standard histamine control and the control reaction of a healthy volunteer. The specific immunoglobulin E (IgE) for sesame was highly positive (6.37 kUA/L, Phadia ImmunoCAP), whereas total serum IgE (93.5 kUA/L) and basal serum tryptase level (3.1 Hg/L) remained in the normal range. Complying with the patient’s wish to avoid unnecessary diet restriction, we conducted a double-blind placebocontrolled food challenge starting with 25 mg of sesame seeds in bread porridge. Fifteen minutes after a dose of 100 mg of backed sesame seed, acute disseminated urticaria, pruritus, and periorbital and periocular edema occurred without reaction of the upper or lower airways. The IgE-mediated mast cell activation was proven by increased serum tryptase level (17.5 Hg/L) 2 hours after the food challengeYinduced anaphylaxis. The increased reporting of allergic type I hypersensitivity to sesame (S. indicum) with major allergens Ses i 1-7 suggests its growing importance. Several recent reports from Pajno et al and Eberlein-König et al describe nonYIgE-mediated sesame anaphylaxis. Our case of classic IgE-mediated anaphylaxis to sesame with primary manifestation in a 70-yearold patient represents the potential life-threatening severity of food anaphylaxis, especially to foods with pronounced allergenic properties such as sesame, irrespective of the patient’s age.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Food Allergy in Lebanon: Is Sesame Seed the "Middle Eastern" Peanut

A randomly sampled, cross-sectional serology test-based survey was conducted in Lebanon to describe the pattern of food allergy among Lebanese population. The prevalence of specific Immunoglobulin E (IgE) to food allergens was investigated in 20 laboratories in different regions of Lebanon by an immunoblot assay over a 1 year period. Clinical correlation was determined in two university hospita...

متن کامل

Allergy to fruit seeds presenting with anaphylaxis

Allergic reactions to fruits, particularly citrus, are relatively common, often presenting with symptoms of oral allergy syndrome (also known as pollen-food syndrome), with systemic allergic reactions occurring less frequently. Fruit allergy testing, including serum specific immunoglobulin E (IgE) and skin prick testing will identify the allergen in most cases, however these tests commonly use ...

متن کامل

Sesame allergy: current perspectives

Sesame is an important global allergen affecting ~0.1% of the North American population. It is a major cause of anaphylaxis in the Middle East and is the third most common food allergen in Israel. We conducted a systematic review of original articles published in the last 10 years regarding the diagnosis and management of sesame allergy. Skin prick testing appears to be a useful predictor of se...

متن کامل

A Case of Immunoglobulin E Mediated Anaphylaxis to Levodropropizine

We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As she was tolerable to acetaminophen alone, we thought the culprit agent was maybe a levodropro...

متن کامل

Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcepsilonRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcgammaRII and III. We ha...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2008